Mount Desert Island Biological Laboratory

159 Old Bar Harbor Rd, Bar Harbor, ME 04609

The benefactor desires that grantee shall use the gift to seek to prevent organ complications in diabetic patients. high glucose levels lead to the pathological changes in the vasculature of different organs such as the heart, kidney, eye and peripheral circulation. the focus is the microcirculation of the kidney. the endothelial cell surface is covered with a layer of glycocalyx. the glycocalyx is very important for the health of the vascular wall and regulates central mechanisms such as metabolism, inflammation, blood pressure, etc. we will test the hypothesis that recombinant hpa2 ameliorates diabetic nephropathy by maintaining a functional heparan sulfate glycocalyx on endothelial cells and monocytes. this is a continuation of the project funded in 2021.

$450k

University Of Florida Foundation

Po Box 14425, Gainesville, FL 32604

The benefactor desires that grantee shall use the gift to seek to test genetic associations with children's response to albuterol and begin a longitudinal pediatric asthma registry combining clinical and genomic data.

$57.5k

Cincinnati Cancer Foundation Inc

Po Box 8280, Cincinnati, OH 45208

The benefactor desires that grantee shall use the gift to establish the advancing precision oncology center ("apoc"), whose purpose is to enable patient access to a wide range of ngs testing intended to facilitate early detection, better outcomes, and better possibilities for cancer cures through earlier detection and intervention.

$350k