The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.
This grant supports exploratory research into the biology of high confidence risk factors associated with complex brain disorders, focusing on the cellular and molecular substrates of neural function. It encourages studies that may be either hypothesis-generating or hypothesis-testing, utilizing various experimental paradigms, including in vivo, in situ, or in vitro approaches. Proposals should aim to elucidate the neurobiological impact of risk factors, without the requirement to model the disorders themselves. Research that enriches data resources for broader scientific utility, particularly in understanding disease risk, biological mechanisms, and therapeutic target identification, is sought. This announcement specifically seeks R21 applications for high-risk or early-stage research.