The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.
This grant supports the development of a comprehensive understanding of the impact of sex differences on brain aging and disease trajectories, particularly focusing on Alzheimer's disease (AD) and AD-related dementias (ADRD). It aims to employ integrative experimental and analytical approaches combining basic and translational/clinical research. The grant encourages the exploration of how genes, environment, and host factors, including hormonal status, influence disease risk and treatment response. The ultimate goal is to advance research programs that produce heterogeneous disease risk phenotypes and improve prevention and therapy for AD/ADRD through understanding sex differences.