The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.
The grant aims to support research on phenotyping and/or the study of embryonic lethal knockout (KO) mouse strains created by the International Mouse Phenotyping Consortium (IMPC). Specifically, it encourages leveraging of these mouse strains for in-depth phenotyping and research to better understand human genetic variations. The grant facilitates access to a growing database of knockout genes and provides a unique opportunity for the scientific community to engage with this resource during its development, particularly focusing on strains that are embryonic or perinatal lethal, or subviable, yet may present viable heterozygous phenotypes for exploration.