The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.
This grant aims to harness the NIH INCLUDE Project's resources to generate extensive genomic and multi-omics data, aiming to unlock the molecular mechanisms underlying health conditions associated with Down syndrome. The initiative encourages applicants to conduct omics analyses on existing biospecimens from individuals with Down syndrome and control groups. Specifically, the grant supports whole genome sequencing, exome sequencing, epigenome mapping, and transcriptome sequencing among other omics strategies. An additional focus is on enhancing racial and ethnic diversity within study cohorts. All resulting data and associated clinical information will be integrated into the INCLUDE Project's controlled-access database, although direct funding to applicants is not provided under this opportunity.