The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.
This grant aims to fund investigations that focus on understanding the cellular and molecular mechanisms behind the interactions of multi-proteinopathies driving the worsening of neurodegenerative processes and phenotypic outcomes. It specifically supports research that examines at least two relevant co-pathologies amongst tau, alpha-synuclein, TDP-43, TMEM106B, and vascular issues, alongside optional research into risk factors and co-morbidities. The research should explore how these co-pathologies interact within various brain regions and over time, their intracellular dynamics, localization, and their effects both upstream and downstream from aggregated protein states, with a goal of uncovering the events that lead to more severe phenotypic outcomes.